The progress of today medical science is oriented to development of new technologies allowing not only highly effective treating diseases, but also preventing them, increasing the vital potential of the organism.
One of such progressive approaches is ozone therapy.
It has a wide range of action in surgery, dermatology, urology, internal medicine. It would be strange if ozone would not be put into use in cosmetology - one of the most progressive fields of its application. In methods of treatment with ozone a particular attention is paid to improvement of microcirculation, oxygenation, energy supply of cells, proper trophism and protection of skin. Many cosmetic problems - acne, teleangiectatic rosacea, outflowing of the hair, wrinkles, allergy, cellulites, fatness - are reflecting the internal state of the organism, therefore they should be treated not only from the outside, but also inside. And this task can be successfully done by ozone producing a detoxication, antimicrobial, antiviral effect and increasing the organism's immunity.
Ozone is a unique agent preserving and restoring the natural beauty and health of skin. Ozone therapy does not mask defects of skin, but normalizes its natural functions and stimulates its own work.
The mechanism of action of ozone can be demonstrated on the example of its use within a complex program for skin rejuvenescence.
Aging at the level of epidermis is induced by inhibition of proliferous cell division, exhaustion of epidermis, increase in keratin layer, decrease in elasticity and increase in residual epidermis deformation ("crow's-foot"), formation of deeper wrinkles.
Skin functions properly and looks young only in case of proper trophism and division of epidermis cells. The natural mechanism of cell trophism is realized by means of tissue liquid, lymph and blood plasma.
The functional efficiency of this network and quality of epidermis trophism are considerably decreased under the influence of negative factors of environment Aging at the level of dermis is induced by changes in the structure of collagenous and elastic fibers. On exposure of collagen to free radicals it comes to "together-sewing" of collagen, therefore collagenase enzyme responsible for collagen degradation in normal conditions is not able to realize its function. It comes to accumulation of pathologically modified collagenous fibers, a decrease in their water-retaining ability and in the total level of water in dermis. It comes to a functional disturbance of hyaluronidase, the specific enzyme producing an effect on hyaluronic acid and defining skin penetrance.
Owing to aging it comes to a decrease in the activity of some key enzymes of respiratory chain and intensity of cytochromoxidase synthesis that leads to energy deficiency in cells. It comes to inhibition of epidermis cell regeneration, exhaustion and fragmentation of elastin fibers, and a result of all these pathological processes is formation of wrinkles.
Skin aging can be inhibited, and skin structure can be restored through neutralization of the above-mentioned pathological processes thereby eliminating the reason, but not only the consequence - formation of wrinkles. Exactly this is the target of ozone therapy. Ozone is a substance created by the nature, produces a complex, integral effect on the human body. For treatment of "problem" skin and wrinkles it is recommended to use the methods of local and systemic ozone therapy: by local route - subcutaneous ozone injections and ozonized olive oil in the form of face packs and for massage; by systemic route - intravenous drop-by-drop infusions (drips) of ozonated solutions, major and minor autohaemotherapy with ozone, rectal ozone insufflations. The approach to treatment and choice of methods are strictly individual for each patient.
Ozone introduced subcutaneously activates metabolic processes in macroergic cells, normalizes active membrane transport (K-Na pump), penetrance, deformability, viscosity and electric properties of membranes. At the same time, it comes to an increase in the intensity of energy processes: on the one hand, through the increased utilization of oxygen by cells owing to activation of aerobic glycolysis, Krebs' cycle, B-oxidation of fatty acids, and on the other hand - through optimization of the oxygen-transport function of blood (at presence of ozone the erythrocytes are able to bond and transfer 10 times more oxygen and more easier release it to tissues). Besides, it comes to stopping of "oxidative stress", activation of the antioxidant defense system and neutralization of the destroying effect of free radicals. It comes to stimulation of protein synthesis including its own collagen and elastin, an increase in the regenerative potential of proliferative skin layer. It comes to an increase in tissue liquid volume in deep layers and restoration of the natural skin ability to retain water, and as a result, it comes to ironing and disappearance of "crow's-foot", deeper wrinkles, and the rejuvenescence effect is well manifested.
The essential difference of ozone therapy from other cosmetic remedies and procedures is its dual action from the outside and inside of the organism that leads to normalization of trophism, oxygenation, moistening, protection and exchange restoration of skin. It helps to achieve general cleaning, sanation and tonization, but not only a temporary cosmetic effect.
Thus, ozone therapy is a revolutionary remedy for rejuvenescence allowing to restore the barrier, immune, water-retaining, reparative and separative functions of skin as well as to improve its structure.
Especially noticeable and fast results through ozone therapy are observed in patients with diagnosis "skin stress".
The most frequent method of administration of ozone for rejuvenescence is by intravenous drop-by-drop route and in the form of ozone bath "torso".
For the organism's cleaning, elimination of roughages and toxins including stress toxins producing a negative effect on skin the complex treatment of skin fading contains global intestinal cleaning. On completing this procedure it is recommended to perform rectal ozone insufflation thereby creating beneficial conditions for regeneration of "healthy" intestinal flora and producing a beneficial effect on the whole organism.
For correction of available signs of skin fading after 35 years of great benefit can be the rejuvenescence courses of ozone therapy in the form of subcutaneous injections at the places of wrinkle localization and other places with manifested skin fading (chin, cheeks, neck). After the procedure it is recommended to perform manual massage - plastithermic or cosmetic for equal distribution of ozone-oxygen gas mixture.
The well-manifested effect is observed already after 3-4 procedures: ironing of fine wrinkles, an increase in skin turgor, a decrease in face pastosity, improvement of face color, appearance of glow. The patients report about a decrease in skin dryness, disappearance of skin constriction sensation even after washing. Both the patients and doctors notice a lifting effect in submaxillary and cheen-chin areas. And what is very important is improvement of general feeling.
Acne disease. Ozone therapy is used in the form of local ozone injections onto inflammatory areas (infiltrates, pustular elements). In some cases it is recommended to perform primary focal sanation by method of electrocoagulation, opening and elimination of purulent content, and then ozone therapy. The depth and number of injections under one focus depends on the size of inflammatory element. Up to 5 ml of ozone-oxygen gas mixture is injected into each point.
On average one treatment course consists of 5-6 procedures at an interval of 5 days. All patients show clinical improvement already after one procedure. This manifests in infiltrate softening, a decrease in swelling, exudation, hyperemia, painfulness. Treatment time is reduced by 2-3 times as compared with traditional methods.
Any complications and side effects are not observed.
In case of torpid course of acne disease, diffused process the most effective method is autohaemotherapy with ozone considerably increasing the immunity and producing an antibacterial effect.
Ozone is also an integral part of postoperative rehabilitation for prevention of complications. Ozone helps to intensify lymphodrainage, restore microcirculation, improve tissue trophism, stimulate metabolic processes.
The effect is noticeable already after one-two procedures: a decrease in edema, tissue thickening and painfulness. After 4-5 procedures it comes to restoration of skin sensitivity, a decrease in hyperemia and disappearance of constriction sensation in the area of postoperative sutures. More comfortable sensations of the patient have a positive influence on his evaluation of results of the performed operation.
After the wide practical introduction of such methods as middle and deep chemical peelings, laser and mechanical skin grinding, injection contour plasty we are facing a serious problem - hypertrophic scars. Ozone gas injections around the scar induce disappearance of skin constriction sensation, paling and softening of scars and their further resorption. As a result, it comes to significant ironing of scar surface, restoration of tissue elasticity.
Obviously, ozone therapy in the form of injections allows solving many serious problems arising in the practice of dermatocosmetologist. Of great importance is the fact that the result of similar procedures is not only solution of esthetic problems being a reason for a visit to doctor, but also improvement in general feeling of patients through the many-sided non-specific effect of ozone on tissues and the organism as a whole.
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