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17 Mar '18

Topical Application of Ozone in Medicine

Posted by Marin Crangaci
To the best of our knowledge, the first application of gaseous O3 was performed during World War I for treating German soldiers affected by gaseous gangrene due to Clostridium anaerobic infections very sensitive to O3.
In 1936, Dr P. Aubourg, by using a metal cannula, was the first to propose the insufflations of gaseous O2/O3 in the rectum to treat chronic colitis, anal ragadis and fistulae. This approach is very empirical and unprecise and today it is mostly used by Cuban physicians. In 1937, a Swiss dentist, E. A. Fisch (1899– 1966) had the idea to use it in his practice and, by a twist of fate, he treated Dr. E. Payr (1871–1946) a surgeon who had a painful gangrenous pulpit. Payr was so enthusiastic of the O3 effect to use it in his surgical practice with great advantag. 
. Later on, Werkmeister mastered the use of gaseous O3 in several skin ulcers due to atherosclerosis, diabetes and radiotherapy by either enclosing a leg in a polythene-bag (the so-called bagging system) or using an ozone-resistant plastic cup applied in other areas. In the former application the gas was introduced to just inflate the bag containing some distilled water.
The system was static but after 20–25 minutes the gas was aspirated and destroyed. The O3 concentrations varied between a high 80 μg/mL in very purulent ulcers and progressively lower concentrations down to 10 μg/mL as the ulcers improved because excessive O3 would be deleterious for healing. As the cup system had an inlet and an outlet, Werkmeister could realize a continuous gas flow with a modest depression that enhanced the vasodilation of the ulcer’s area. With both systems he treated many extensive and otherwise incurable lesions within 50–200 days. It is noteworthy that gaseous O3 works well only in a water vapour-saturated bag because it must dissolve into superficial water or in the exudate to react proficiently. The normal skin does not undergo any damage during the treatment. Today these procedures are still in use but they are somewhat cumbersome and great care must be exercised to prevent air contamination.
How ozonated oils act remains an open question. Probably, when the stable triozonide comes into contact with the warm exudate of the wound, it slowly decomposes into different peroxides, which readily dissolves in water, probably generating hydrogen peroxide that can explain the prolonged disinfectant and stimulatory activity.
If it is correct, this reasoning implies that we should have titrated preparations with high, medium, or low ozonide concentrations to be used during the inflammatory septic phase I, regenerating phase II or remodelling phase III, respectively. These phases have been related to the rapidly changing cell types and to the release of cytokines and growth factors that modulate the complex healing process.
An alternative method for treating diabetic foot ulcers is the use of hyperbaric oxygen therapy (HOT) but in such a case one disadvantage is the use of only hyperbaric O2 and another is the need to close the patient in the chamber for two hours. Therapeutic results are far more modest than topical O3 application, particularly when it is contained in a close cabinet with thermostatically-controlled temperature. However this procedure requires considerable idle times and, if an aspirating pump is unavailable, it may contaminate the operating room.
For these reason today for cleaning and disinfecting cutaneous and mucosal infections and lesions due to many causes (like, e.g., trauma, ischemia, burns), it appears preferable to use at once freshly ozonated water and then ozonated oil, particularly during the night or at rest conditions. 
The process of water ozonation needs of double distilled water and O3 concentrations ranging from 20 up to 100 μg/mL of gas to have a final yield of 5 up to 25 μg/mL, respectively. O3 is directly bubbled into the water and the gas in excess is passed through a dehydrating device and finally through a destructor. Depending upon the water volume and the gas flow, a period of ozonation between 5– 20 minutes is sufficient to saturate the water with gaseous O3. In fact, if the water is ultrapure, O3 physically dissolves in the absence of chemical reactions and if kept in a glass bottle closed with a Teflon cap, the concentration halves only after 300 hours at 0◦C. However, at 20◦C the half-life is about 10 hours. It must be noted that monodistilled water allows a much faster O3 decomposition and it is not practical. It is adviced to maintain the bottle at 4◦C and to quickly close the bottle at any time, or better to have a valve system to prevent gas losses.
It would be useful to device a procedure for maintaining the O3 concentration for longer times and we are investigating a possible procedure. On the other hand, ozonation of either olive or sunflower oils requires a much longer time and the procedure needs to be well-standardized in terms of gas-flow, O3 concentration, oil volume, and temperature. As recently reviewed, at least twenty different vegetable oils have been patented but so far it remains impossible to define their relative cost/benefit. At this stage, after evaluating several physicochemical criteria, stability, efficacy, and cost, it seems that sesame oil has several advantages in comparison to other oils.

How and when ozonated water and oils are used?

Chronic wounds range from diabetic foot to putrid and deep ulcers due to limb atherosclerosis, or trauma and burns. Moreover, both immunosuppressive chemotherapy and/or malnutrition cause abscesses, anal fissures and fistulae, bed sores, furunculosis, and osteomyelitis which are difficult to treat and often fail after prolonged treatments. About 7 million patients in the United States are affected with a cost over US$ 25 billion annually.
Various types of disinfectants, antibiotics, antifungal, antiprotozoal, and growth factors are scarcely effective because the deranged metabolism and local hypoxia are not modified. Several other approaches such as vacuum therapy, maggot therapy and devices for providing topical oxygen therapy in a clinical setting have been proposed and variably used. This last approach has a rationale in the sense that enhanced oxygenation is useful for activating the metabolism and cell proliferation of ischemic tissues. However, it has also considerable limitations because it is a cumbersome therapy, with minimal disinfectant activity and modifications of the fundamental pathogenetic mechanisms.
Another topic of critical interest is the pathologies of the vaginal mucosa. Although rarely deadly (as the toxic shock syndrome due to a forgotten absorbent tampon), a majority of women physically and psychologically frequently suffer from a number of infections due to several pathogens such as Neisseria gonorrhoeae, Trichomonas vaginalis, Candida albicans, Chlamidia trachomatis, Herpes virus type-II (HVII), human papilloma viruses (HPV), human immunodeficiency virus (HIV), often due to unprotected sexual intercourses, stress, change in sexual partners and also physiological hormonal changes during menopausa. About 20 million Americans are affected by the distressing HV-II and as many 40 million have the genital HPV with warts and the impending risk of cervix cancer. Moreover, the further implantation of opportunistic infections complicates the treatment
It is unfortunate that orthodox medications are expensive and not so useful because of drug-resistant pathogens and side effects limiting the compliance. So far official medicine has not yet entertained the topical use of O3 and derivatives in therapy because they are not profitable and no extensive clinical trials have been published in peer-reviewed journals: the therapy has remained in practitioners’ hands and the results remain anecdotal. Moreover, the parenteral use of ozone, also known as ozone therapy, is very useful as adjuvant: it is reasonably ease to perform in terms of classical ozonated major and minor autohemotherapy. 
The latter modality has been successfully used for eliminating recurrences of HV-I and II infections. However, topical therapy is essential and it is carried out by using vaginal irrigation of fresh ozonated water and application of vaginal ozonated oil pessaries for the night. During prolonged treatment the ozonated compounds allows the elimination of any pathogens. So far no resistance to O3 has been demonstrated. Creams containing ozonated oils can be used 3-4 times daily for external genital areas and also for several anorectal affections.
As for the oral infections (aphthae, HV-I, opportunistic superinfections, or acne) the earliest as possible application of ozonated ointments, by minimizing pathogen diffusion and enhancing microcirculation, reduces the swelling, destroys the pathogen, and allows a rapid healing. Last but not least, clinical trials in tinea pedis as well as onychomycosis have been recently published and have shown the usefulness of ozonated sunflower oil.


At the present, especially in young people, venereal infections are increasingly frequent and therefore a suitable, effective medication with ozonated compounds will be a huge economical and social value. Also, elderly people are burdened with a variety of wounds and ulcers, some of which never heal, making life miserable. It is hoped that the the great number of research will inform official medicine for advance of ozone therapy and will incite to programme suitable clinical trials to show the full efficacy of ozone therapy by evidence-based medicine.
08 Mar '18

Ozone Therapy in Medicine and Dentistry

Posted by Marin Crangaci


Ozone gas has a high oxidation potential and is 1.5 times greater than chloride when used as an antimicrobial agent against bacteria, viruses, fungi, and protozoa. It also has the capacity to stimulate blood circulation and the immune response. Such features justify the current interest in its application in medicine and dentistry and have been indicated for the treatment of 260 different pathologies. It can be used for the treatment of alveolitis as a replacement for antibiotic therapy, as a mouthwash for reducing the oral microflora, as well as the adherence of microorganisms to tooth surfaces. Ozone has been shown to stimulate remineralization of recent caries-affected teeth after a period of about six to eight weeks.

Ozone Toxicity

Ozone inhalation can be toxic to the pulmonary system and other organs. Known side-effects are epiphora and upper respiratory irritation, rhinitis, cough, headache, occasional nausea, and vomiting. However, complications caused by ozone therapy are infrequent at 0.0007 per application. In the event of an ozone intoxication the patient must be placed in the supine position, inhale humid oxygen, and take ascorbic acid, vitamin E, and nacetylcysteine. Because of ozone’s highly oxidative power, all materials that come in contact with the gas must be ozone resistant, such as glass, silicon, and Teflon.

Ozone Therapy Contraindications

The following are contraindications for use of ozone therapy: 
• Pregnancy
• Glucose-6-phosphate-dehydrogenase deficiency (favism)
• Hyperthyroidism
• Severe anemia
• Severe myasthenia
• Active hemorrhage

Methods of Administering Medical Ozone

Because of its high oxidative power and effect on bacteria, viruses, and fungi, ozone therapy is indicated in the treatment of 260 different pathologies. Systemic administration of ozone gas has been carried out using different methods as described below.

Major Autohemotherapy

This is an extracorporeal blood treatment with ozone gas followed by the intravenous reinfusion of the patient’s treated blood. It is indicated for treatment of arterial circulatory disorders, infections, and for rheumatic arthritis. It is also useful in the promotion of immunoactivation, provides additive therapy for geriatric carcinoma patients.

Autohemotherapy promotes:

• Activation of red blood cell metabolism with an increase of 2.3-diphosphoglycerate and Adenosine Triphosphate (ATP) plus improving O2-release to the tissues.
• Activation of immunocompetent cells with release of cytokins, such as interferons and interleukins.

Minor Autohemotherapy

This is an extracorporeal blood treatment and intramuscular injection. It is indicated for allergies, acne, furunculosis, and adjuvant cancer therapy. The mechanism of action deals with a nonspecific activation and general stimulation of the immune-system.

Rectal O3/O2 Insuflation

This method of administration is indicated for arterial circulatory disorders (stage II), general immunoactivation, adjuvant cancer therapy, and hepatitis A, B, and C. The effects are virtually equal to those of major autohemotherapy

The Use of Ozone in Dentistry

Interest in ozone use in dentistry is due to the infectious diseases associated with the oral cavity. Ozone therapy presents great advantages when used as a support for conventional treatments, for example, to dental caries, periodontal procedures, and endodontic treatment.

Ozone Therapy in Surgery

In a clinical survey involving 11 patients Stübinger et al. described the local effectiveness of ozone on infected intraoral wounds following high-dose radiotherapy.
Guerra et al.  compared the use of ozonated oil (Oleozon, Cuba) in an experimental group to a control group in which Alvogil and antibiotic therapy was used in the treatment of alveolitis. Patients treated with Oleozon healed more quickly without the need for systemic medication when compared to the control group. This finding suggests ozonated oil might be effective in the treatment of alveolitis.


For the reasons discussed, the future of ozone therapy must focus on the establishment of safe and well-defined parameters in accordance with randomized, controlled trials to determine the precise indications and guidelines in order to treat various medical and dental pathologies.
Scientific support, as suggested by demonstrated studies, for ozone therapy presents a potential for an atraumatic, biologically-based treatment for conditions encountered in dental practice.
26 Feb '18


Posted by Marin Crangaci
The news about oil pulling and all its many benefits has really spread the last couple of years, especially since using coconut oil for the process has become so popular.
There’s a breakthrough in oral health that has the potential to help millions. It’s an ozonated oil pulling remedy that you swish around your mouth for a few minutes each morning to radically transform your oral health.
The practice of “oil pulling” has been used for thousands of years to pull toxins from gum tissue in the mouth.* It’s a mainstay tool of Ayurvedic Medicine and many people swear by its benefits. But now we’ve taken oil pulling into the 21st century with the addition of an ozone infusionright into the oil.
Ozone, the same elemental molecule you can smell in the air after a lightning storm, is now being used to radically transform modern dentistry. What dentists have discovered is that ozone kills bacteria throughout the mouth, including in tiny, microscopic crevices. Today, more and more dentists have become aware that old root canals may harbor dangerous bacteria and release toxins into the mouth which get swallowed into the body.
TOP 7 BENEFITS of ozonated oil pulling: 


There is no need for chemical teeth whitening strips when ozonated oil pulling works just as well! The ozonated oil possesses natural antibiotic and antiviral properties that brighten and cleans teeth, keeping them pearly white. Try it for two weeks and you’ll see what I mean, or just take a look at Gwyneth Paltrow’s smile. She is known to follow the practice each morning.


When our immune system is put to work in clearing out toxic waste from our body, it drains our energy levels. Removing the noxious culprits in the first instance by ozonated oil pulling lowers the amount of work our body has to do to function, which leaves us feeling a whole lot better.


Germs in the body are much like poison causing inflammation and leading to disease and illness in turn. The gateway to the body for such contamination is the mouth. Therefore, in removing the toxins at the source before they get a chance to spread, the body undergoes a complete detox. 


Without having to compete with foreign substances, hormones can behave as they should, functioning to their best ability without being thrown off balance.


When the body is under toxic stress, headaches and migraines occur. It is nature’s way of asking for some time out to recover. By eliminating bacteria from the body via ozonated oil pulling, headaches can be avoided. 


The benefits even extend to your skin! Removing toxins from the body that would otherwise make it into the bloodstream means the skin has a chance to shine. Rashes and skin issues often reduce dramatically, or even clear up completely, when ozonated oil pulling.


Ozonated oil pulling is highly effective at reducing tooth cavities and at eradicating bad breath. Removing the Streptococcus mutant bacteria (an important player in tooth decay) as well as other microorganisms, ozonated oil pulling is great for oral health. It also helps with plaque-induced gingivitis.

When you start ozonated oil pulling, you might experience some of the positive effects immediately, or it may take a few days or even weeks. It will very much depend on the state of your health to begin with, and how compromised your immune system is. 

Oil Pulling Instructions

  1. Put 1-2 teaspoons of ozonated oil into the mouth. The oil traditionally used in oil pulling is ozonated coconut oil. It is also possible to do oil pulling with ozonated olive oil. Whichever oil you choose, place 1-2 teaspoons in the mouth. 
  2. Swish for 20 minutes. Apparently the timing is key, according to Dr. Bruce Fife, author of Oil Pulling Therapy, as this is long enough to break through plaque and bacteria but not long enough that the body starts re-absorbing the toxins and bacteria. The ozonated oil will get thicker and milky as it mixed with saliva during this time and it should be creamy-white when spit out. It will also double in volume during this time due to saliva.
  3. Spit oil into the trash can. The oil may thicken and clog pipes. Do not swallow the oil as it is hopefully full of bacteria, toxins and pus that are now not in the mouth!
  4. Rinse well with warm water. Warm water seems to clean the mouth better. We recommend you to rinse a few times with warm water to get any remaining oil out of my mouth. Some sources recommend swishing with warm salt water.
  5. Brush well!

16 Feb '18

Amazing Benefits Of Grapeseed Ozonated Oil For Skin, Hair & Health

Posted by Marin Crangaci

Grapes, including its leaves and sap, have been traditionally used throughout Europe for thousands of years to treat numerous conditions.

Grape seed extract, also called grape seed oil, is usually made from the seeds of red grapes used for wine. This oil has been shown to have many benefits for one’s health, including the face, skin and hair.

Grape seed oil was once the well-kept secret of many traditional cosmetic repertoires. It's an easily absorbed, gentle oil that is light on the skin. Known in the cosmetics industry as a carrier oil, grape seed oil facilitates a wide array of commercially available creams and lotions. While you may have no qualms about paying for high-priced cosmetics, you could easily apply the lotion directly from the bottle to enjoy its soothing benefits.

Grapeseed ozonated oil can be used to treat and prevent symptoms associated with aging, such as wrinkles and loose skin. Not only does it help by moisturizing your skin, but its anti-oxidant properties destroy free radicals that degrade collagen production, a substance important for youthful skin.

Simply apply to the face before bedtime and allow to soak in. Make sure to keep oil away from your eyes. Applying the oil after a hot bath will help it soak in more. Consistent use will bring much more noticeable results.

Sun Protection

Although it’s not sufficient to replace sunblock entirely, especially during intense sun, grapeseed ozonated oil has been shown to have some resistance to ultraviolet radiation. Furthermore, the vitamin E contained within the oil prevents skin inflammation that results from sunburn.

Because of it being an oil, it will have sufficient water resistance, making it great for water activities. However, grapeseed ozonated oil tends to absorb in the skin rather quickly, so it may need to be applied frequently to be used as an effective sunblock. Again, remember to use regular sunblock as well.



This trick is especially useful if you get dry skin during the winter, or any time of the year. Climate plays a part as well. However, grapeseed ozonated oil will rapidly heal any dry skin that you may have.

On top of containing healthy essential oils that keep skin hydrated, vitamin E and antioxidants further prevent skin from drying out. Better yet, grapeseed ozonated oil will not clog your skin pores, unlike other moisturizers, so acne and unwanted pimples won’t be a problem.

Severely dry skin may require copious amounts of the oil. It could also be made into a paste, allowing larger doses on the skin at one time.

Not only does grapeseed ozonated oil not cause acne, but it can prevent it too, due to its excellent anti-inflammatory and anti-microbial properties. Another mechanism of how it works is by replacing sebum, a substance naturally produced by the skin to prevent dehydration, is effectively replaced by the grapeseed ozonated oil.

It’s this sebum that feeds acne-causing bacterial. Grapeseed ozonated oil kills the bacteria by replacing the sebum, effectively starving it of food. Any painful pimples or other skin rashes will be soothed by the oil’s anti-inflammatory properties.

Bags under the eyes aren’t reserved for just the elderly, but can be found in just about every age group from 20 and up. A rough lifestyle, such as stress and poor sleep, can add to the mess as well.

Fortunately, applying grapeseed ozonated oil on any eye bags you may have will help alleviate their presence. Also, it can improve lines around the eyes as well.

Although some have reported improvement with dark circles, it may or may not heal your dark circles, due to them having a very different cause.

Stretch marks result from the break down of the dermis, the thickest part of the skin. Sudden growth spurts, such as puberty and pregnancy, cause this. Applying grapeseed oznated oil to the marks will reduce their presence to a degree, especially if you apply frequently.

Applying the oil before a pregnancy will prevent and treat stretch marks even more. You could also apply grapeseed oznated oil to a warm or hot bath, allowing the oil to slowly soak all over.

Pre Shave Oil

Grapeseed ozonated oil makes an excellent pre-shave solution. It will greatly decrease the chance of razor burns during a shave by lubricating the surface between the hair and the razor, effectively preventing the blade from grabbing and pulling.

Any little irritation that does result from the shave will easily be repaired by the oil’s amazing anti-oxidant, moisturizing and collagen-building properties. To make an even more effective grape seed pre-shave oil, heat up oil and add beneficial herbs, then strain them out.

Due to the excellent properties of grapeseed ozonated oil, it makes an excellent substitute for hair conditioner. What’s nice about using grapeseed ozonated oil as a hair conditioner compared to other oils, such as coconut and olive oil, is that it won’t leave your hair feeling greasy and oily.

That fact that it’s odorless is also nice. Overall, it will treat dry hair, split ends and other annoying hair problems you may encounter. Start with a little at first and work your way up. The length of time the oil has to soak is an important factor as well.

06 Feb '18

Amazing Benefits Of Coconut Ozonated Oil For Skin

Posted by Marin Crangaci

Coconut ozonated oil is famous throughout the world not only as an edible oil and hair tonic but also as an excellent massage oil and a moisturizer for the skin. In the tropical parts of the world where coconuts are readily available and used in many ways, natives use coconut oil for skin, as they believe that it protects from the sun’s harmful rays. So this natural oil, without any chemical or additives, can protect the skin in the hottest and sunniest places on earth better than the processed and artificial sun creams.

The best aspect of coconut ozonated oil that makes it so beneficial for skin is that it does not become rancid. When you apply it on the skin, it can work for a longer time, unlike many other ozonated oils, without getting rancid. Due to these various beneficial properties of coconut ozonated oil, it is used as an important ingredient in several skin care creams.

Benefits Of Coconut Oil For Skin Care

Coconut oil can be used for skin care in the following ways:

Lip Gel

Cracks in our lips can be a source of worry, discomfort, and embarrassment. Applying chemical gel to the lips can make you consume some of the gel even though it is toxic. Some types of gels are edible, but you still don’t want to eat those chemicals. Coconut oil comes as an ideal alternative in such cases. It acts quickly and even if it goes in your stomach, it will only give you additional benefits!

Skin Softener

Coconut ozonated oil is a great skin softener and helps you do away with dry and hard skin conditions. Simply take some coconut ozonated oil on your palms, rub your palms against each other once or twice and then on your face, hands or wherever you want to see the moisturizing effect.

Coconut ozonated oil is also good for hardened and cracked feet, which may happen due to excessive cold or strenuous work that requires standing. The cracks in your feet will not vanish, but your feet will become softer within days if you apply coconut ozonated oil to the affected area.

As an exfoliant, including coconut ozonated oil with other exfoliating or grainy materials like salt and sugar, can vastly improve the effects. You will successfully be able to scrape off excess dead skin and clean out the substances that have blocked the pores without leaving the skin feeling irritated. The natural soothing nature of the oil combines with the grainy, exfoliating material perfectly, and leaves your skin with an even color, closed pores, and a soft texture.

Makeup Remover

Coconut ozonated oil can also be used as a makeup remover. This is not common, but women around the world have begun using it for removing their makeup, without worrying about the harsh chemicals of other removers getting into delicate or sensitive areas.

Skin Disorders

It is claimed that coconut ozonated oil is good for several skin disorders such as acne, psoriasis, and eczema. Several readers have reported this benefit. However, scientific research is ongoing in order to prove or deny these claims. Much of the research speaks of its protein content since the replacement of sick or dying cells that can occur with various skin disorders are quickly replaced by new, healthy cells. In this way, coconut ozonated oil not only treats the infection by battling the microbial bodies, they also heal the damage or the visible marks of that skin disorder; it is a two-in-one solution!

Anti-aging Cream

Traditionally, coconut oil has been praised and popularized for its anti-aging properties.

How To Use Coconut Oil For Skin Care?

For skin care, take some coconut ozonated oil, on your palm. Then, rub your palms together and onto the skin of the desired area. You can also put coconut oznated oil on a piece of cotton and rub it onto your skin. However, it is not necessary to reapply coconut ozonated oil as often as other natural skin care oils; you only need a small amount to create a protective shield on your skin that will last for a long time.

Many people make the mistake of using too much coconut ozonated oil, and since the skin can only absorb a certain amount, the protective layer that the absorbed oil creates doesn’t let any more oil in! This means that if you use too much, too often, your skin will end up as an oily mess, and will look shiny or greasy, not to mention what it might do to your clothes! Then, go get yourself some coconut ozonated oil and bring your skin back to its natural beauty!

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