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26 Aug '18


Posted by Marin Crangaci

What is cellulite?

Cellulite is the dimpled appearance of the skin that some people have on their hips, thighs, and buttocks. Cellulite is much more common in women than in men because of differences in the way fat cells, muscle, and connective tissue are distributed in men's and women's skin. Fat deposits that push and distort the connective tissues beneath skin cause the appearance of lumpiness, leading to the characteristic "cottage cheese" changes in the appearance of the skin. Physicians refer to cellulite as edematous fibrosclerotic panniculopathy (EFP).
Cellulite is unrelated to the condition known as cellulitis, which is a spreading bacterial infection or inflammation of the skin and tissues beneath.

What causes cellulite?

The dimpled appearance of cellulite is a normal variant -- one way that many perfectly normal human beings look. Heredity, skin thickness, gender, the amount and distribution of body fat, and age can all influence the extent to which cellulite is present or visible. Cellulite occurs due to shrinkage or shortening of the fibrous tissue cords that anchor the skin. While cellulite is more common in women than men, men also can develop cellulite. Cellulite occurs in people of all races living all around the globe. Although female hormones may play a role in contributing to this pattern of fat distribution, cellulite is not treatable by hormone therapy.

 The initial stage of cellulites is characterized by microcirculatory disorder, swelling, stagnation of liquid in subcutaneous tissue. So, it comes to edematous form of cellulites that in case of further progression is transformed to fibrosclerotic form.  Thus, the main mechanism of cellulites development is microcirculatory disorder that leads to edema, which in turn aggravates hemodynamics closing circulus vitiosus.

Cellulites treatment should be focused:
Firstly, on removal of disease reason;
Secondly, on correction of pathogenetic mechanisms of disease development;
Thirdly, on liquidation of its appearances and consequences.
All these tasks can be successfully fulfilled by ozone.
 It is mostly rational to start cellulites treatment on early stages when it only represents an esthetic problem. In this case ozonated oil can be used as a mono therapy, and it takes a few procedures with the ozonated oil massage to achieve a good cosmetic effect. The program of cellulites therapy combines local ozonated oil therapy (massage and wrapping on ozonized olive oil). The parenteral methods restore hormonal background, protein, fat and carbohydrate metabolism, quickly remove consequences of stress and chronic tiredness, balance the processes of excitation and inhibition of nervous system, increase oxygen supply of the whole organism.
              Before                                                   After

   The usual course of massage therapy includes a certain number of sessions (from 10 to 20) with frequency 2-3 times a week. Positive results of treatment are observed already after 3-5 sessions and well manifested, the patients start to notice lightness in the lower limbs and a decrease in pastosity and edema. On the next stage it comes to reduction or complete disappearance of "orange peel", a decrease in volumes of subcutaneous tissue. Through ozonated oil therapy it comes to a fast-progressive decrease in fat layers, fatty tissue becomes more thick and compact.
  Ozone facilitates fast elimination of fat from stomach, particularly from its lower part that undergoes a little change through traditional methods of correction and practically no change through diet therapy and general slimming.

   The essential difference of ozonated oil therapy from other forms of lipolysis (mechanical, electric, ultrasound, chemical) is that ozonolipolysis or ozonolysis (destruction of fatty tissue by ozone) combines both a local and systemic detoxication effect, intensifies fat splitting and utilization. It comes to stimulation of cellular processes, an increase in the oxygen-transport function of blood and accordingly the oxidoreduction potential of the organism. Ozone introduced by parenteral route does not only activate lipid exchange, but also initiates the mechanism of natural processing of the organism own energy resources i.e. fat. Ozone stimulates B-oxidation of fatty acids, energy production and activity of the hepatocytes focused on processing of lipid fractions; on this way liver is not affected.    Under the action of ozone in the hepatocytes it comes to activation of structural-functional mechanisms of transformation of fat energy substrates to carbohydrate ones. Ozonization induces production of catalase and peroxides involved in the catabolism of fatty acids and synthesis of glycogen and glucose from products of this catabolism i.e. ozone performs the antioxidant and detoxication functions.    The anticellulites effect and slimming are realized on a background of tonus restoration, strengthening and tonization of all tissues exposed to ozone therapy. Skin is not hanging like after usual slimming and other methods of cellulites treatment, on the contrary - it becomes more elastic, its appearance improves. It comes to normalization of connective tissue structure as ozone has a fibrinolytic effect, a decrease in the level of hypertrophic adipocytes and metabolism restoration in subcutaneous tissue.
   As a rule, cellulites is not an independent pathology, but manifests on a background of the main disease owing to the organism's intoxication. Therefore, without removing a reason it is impossible to cure a consequence. Ozone producing a complex effect on the organism acts on the molecular, cellular, systemic levels and treats both actual diseases and their consequence i.e. cellulites. Ozonated oil therapy provides remission for half to one year, but not only 1-2 months like traditional treatment. So, ozone is used to treat cellulites, but not only to achieve a temporary cosmetic effect. Based on the results of numerous clinical investigations it can be claimed that for today ozone therapy is one of the most effective methods for prevention and treatment of cellulites.

   The gathered experience allows making a conclusion that ozone therapy is characterized by simplicity of application, good tolerance by patients, practically complete absence of side-effects, high efficiency and reasonable prices for appropriate equipment. This is a very profitable method of treatment.
16 Aug '18

Oils-use and benefits

Posted by Marin Crangaci

We offer our clients not only the curative effects of ozone but also the many benefits of high quality oils we use in the production of ozonated oil. Today we will try to show where the rich variety of benefits of ozonated oil comes from.


Oils have been used for thousands of years in various cultures for medicinal and health purposes. Because of their antidepressant, stimulating, detoxifying, antibacterial, antiviral and calming properties, oils are recently gaining popularity as a natural, safe and cost-effective therapy for a number of health concerns.

There’s no wonder why, considering the high cost of healthcare bills and the side effects of conventional medications, adding ozonated oils to your personal medicine cabinet can make a world of difference. This is especially true because ozone + oils benefits are vast and their uses range from aromatherapy, household cleaning products, personal beauty care and natural medicine treatments.

The Benefits of Hemp Oil

  • Balanced ratio of Omega-6 and Omega-3 fatty acids:  Hemp oil has a 3:1 ratio of these important fatty acids.  This is thought to help reduce the symptoms of psoriasis, acne and eczema.  It is also prized for those on vegan diets and for promoting heart health.
  • A variety of hair and skin benefits:  Many people who use hemp oil report thicker, smoother hair, softer skin and stronger nails.  
  • Good source of GLA (gamma-linolenic acid):  A rival to Evening Primrose and flax seed oil as well as an alternative to fish oil.
  • Natural antioxidant:  Hemp oil has amino acids, Omega-9 and Vitamin E, as well as calcium and potassium.  
  • Anti-inflammatory:  Natural fighter of inflammation, when combined with its antioxidant properties, it can help clean and detoxify your skin.

When hemp oil is infused with ozone (activated oxygen), it has a gel-like consistency that is water-resistant and very strong.  Ozonated hemp oil is made by bubbling high grade, highly concentrated ozone into organic hemp oil.  Instead of using ambient air, we use medical-grade oxygen that keeps nitric oxides from entering the oil.  The high quality is preserved during ozonation by using only the finest cold plasma ozone generators to make sure no heat is produced that can harm the oil.  The end result is the purest, freshest ozonated organic hemp oil available.

Combining the benefits of hemp oil with the curative effects of ozone finally gives a product with a wide range of therapeutic indications. You can read more about in this article.

Olive Oil Benefits

Boost Immunity & Fight Infections 

Olive oil have anti-inflammatory, antiviral, antibacterial, antiseptic and anti-fungal properties that help to boost your immune system and fight infections. The chemical substances found in olive oil, such as terpenes, esters, phenolics, ethers and ketones, have the potential to fight foreign pathogens that can threaten your health. 

 Olive oil+ ozone effectively destroy several fungal, viral and bacterial pathogens, including methicillin-resistant Staphylococcus aureusHelicobacter pylori and Candida albicans infections. Because antibiotic resistance is becoming such a major threat in modern health care, using ozonated oil as a form of independent or combination therapy can help to fight bacterial infections in a safer and more natural way.

Almond Oil Benefits

This oil is rich in many important nutrients. It has high levels of mono and polyunsaturated fatty acids, and vitamins like A, B1, B2, B6, D and E. Sweet almond oil makes an excellent carrier oil, with respect to aromatherapy. It is very safe to use sweet almond oil, as there are no side effects related with this oil. It greatly helps to soften, and recondition skin and hair, which makes it excellent for hair. Many nutrients are required by hair to grow strong and healthy. Vitamin E for hair health is fairly common knowledge, and almond oil with its high levels in this vitamin can greatly help for hair growth and hair conditioning.


There are many sweet almond ozonated oil benefits for hair. Many hair care products also have almond oil in them, to nourish and care for hair. Almond oil greatly helps to nourish hair and smooth hair cuticles. It also makes hair strong, long and thick. You can use almond oil for massaging scalp, to increase blood circulation. And by applying it to hair, you can add shine to dull hair. As almond oil makes an excellent carrier oil, you can mix it with neem oil or tea tree oil and use it to massage the scalp, whenever suffering from dandruff. If you wish to control hair fall, then by regularly applying almond oil to your hair, you can greatly reduce hair fall. Mixing it with other essential oil like lavender oil and rosemary oil can also help.

06 Aug '18

The Benefits of Ozonated Oil

Posted by Marin Crangaci
Ozone Factory cosmetic products line is based on ozonated certified organic oil, which has very useful biological benefits for your entire family's skincare regime as well as for naturally treating some of the most common conditions, such as redness, skin irritation, dermatitis, bedsores, herpes, poor circulation, scars, breakouts, rashes, ulcers, rubbing dryness…
  • It protects the skin against external aggressors.
  • It is deeply moisturizing and nourishing.
  • It purifies, regenerates and repairs the skin. It helps the healing process.
  • It improves blood circulation and associated problems (ulcers, severe dry skin…).
  • It controls and prevents the proliferation of germs present in some skin conditions (acne, seborrhea, skin lesions…).
  • It improves cellular metabolism and strengthens the natural anti-inflammatory system.
  • It treats problematic or damaged skin (redness, bedsores, scars...).
  • It helps to avoid the use of medical treatments such as corticosteroid creams.

Ozonated oil is appropriate for treating damaged skin:

  • Diaper rash, the irritation and redness caused by diapers in babies or the elderly.
  • Skin types that suffer from acne or seborrhea (pimples, blackheads, dandruff, dryness, eczema).
  • Ulcers, herpes and bedsores, especially among the elderly and people with reduced mobility.
  • Anal itching, inflammation and irritation, hemorrhoids, intimate feminine care…
  • Skin repair for dermatitis, inflammation, reddening, dryness, itching, scratches, rubbing, scars
  • Foot treatment and moisturizing. Prevention of foot disorders. Effective in treating the skin of diabetic foot and feet exposed to external aggressors (pools, spending a long time standing, uncomfortable shoes, etc.).
  • Problems with blood circulation and dryness in the legs (women, men, the elderly). Improves metabolism.
  • Insect bites and stings and contact dermatitis caused by allergens, chemical irritants, plants, etc.

Ozonated oil is also helpful for general skincare for adults, teens and children: it moisturizes, nourishes, and protects against external aggressors, with antioxidant, purifying and regenerative properties.

Ozone and ozonated oils

Ozone is a gas with the chemical formula O3. It is the allotropic form of oxygen (O2), meaning that it is oxygen in its most active state. It is found naturally in the environment as well as in the ozone layer, which protects the planet from the sun’s ultraviolet radiation. Ozone’s main feature is its incredible ability to purify, eliminating organic compounds including bacteria, fungi and viruses. When applied directly onto them, ozone has an immediate effect and the only residue that it leaves behind is pure oxygen. This makes it an extremely effective natural germicide agent. In the case of ozonated oils, the ozone reacts with the fatty acids in the oil under controlled reaction conditions, creating peroxide species, lipoperoxides, ozonides, aldehydes and ketones, among other compounds. According to multiple studies, the synergy that is created between the ozone and the oil explains the immense benefits of ozonated olive oil for the skin: its germicide power against bacteria, viruses and fungi; its anti-inflammatory, antioxidant (because it stimulates the endogenous antioxidant system) and immunostimulant properties; its ability to repair and heal tissues; its moisturizing and nourishing capacity; its role in protecting against external aggressors, improving the metabolism, etc.


27 Jul '18

Ozone Therapy in Herpes Simplex and Herpes Zoster Diseases

Posted by Marin Crangaci


We are famili ar with herpesviruses, because most of us have suffered their infection. Herpesviruses are associated with multiple human disorders, ranging from mild symptoms such as cold sores to more severe diseases, such as cancers. For instance, oral herpes is caused by herpes simplex virus type 1 (HSV-1). Here, HSV-1, a prototype of human alpha-herpesvirus, will be mainly described. Besides HSV-1, human cytomegalovirus (HCMV), a prototype of beta-herpesvirus, and Epstein Barr virus (EBV), a prototype of gamma-herpesvirus.

1. Herpesvirus -the term “herpes” is derived from Greek word for “creep=latent or chronic”-herpin.
2. Epstein-Barr virus (EBV)- a human gamma-herpesvirus that is associated with Burkitt’s lymphoma. The virus was named after two scientists who discovered: Dr. Epstein and Dr. Barr.
3. Tumor virus-five human viruses, including EBV and KSHV, are known to be an etiologic agent for human cancer.

Eight species of human herpesviruses have been discovered. Human herpesviruses are divided into three genera: alpha-, beta-, and gamma-herpesviruses.

In alpha-herpesviruses, three species are reported:

(1) herpes simplex virus type 1 (HSV-1), which causes cold sores or oral herpes

(2) herpes simplex virus type 2 (HSV-2), which causes genital herpes               

(3) Varicella-Zoster virus (VZV), which causes chicken pox in children and shingles in adults.

Beta-herpesviruses include human cytomegalovirus (HCMV), which causes cytomegalic inclusion disease, and human herpesvirus 6 and 7, which cause roseola.

In gamma-herpesviruses, two species are reported: Epstein-Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV). EBV is associated with two types of human cancers:
Burkitt’s lymphoma and nasopharyngeal carcinoma. KSHV is associated with Kaposi’s sarcoma in AIDS patients. These human gamma-herpesviruses are tumor viruses.In addition, human herpesviruses are systemically named by the
order of discovery, from HHV-1 to HHV-8.


Cell tropism: HSV-1 infects the epithelium of the mucosal layer. Following primary infection, HSV-1 invades the central nerve system (CNS) via sensory neurons and finally establishes latent infection in nerve ganglia.Similar to other DNA viruses, the virus life cycle can be divided into two phases by the onset of viral genome replication: early phase and late phase. The viral genome replication occurs in the nucleus of infected cells.

Patterns of Virus Infection

Outcomes of virus infection mainly rely on host immune response to virus infection. Depending on the extent of viral replication and pathogenesis during the course of infection, the pattern of viral infection can be divided into four kinds. First, depending on the viral persistence following primary infection, virus infection can be divided into two patterns: transient infection and persistent infection. In clinical circumstance, the former is often termed “acute infection,” while the latter is termed “chronic infection.” Acute infection refers as a viral infection limited by host immune response. Following primary infection, viruses are cleared from the body. Influenza virus and rotavirus infection are two representative examples. In contrast, chronic infection refers to a viral infection that evades host immune response and maintains viral replication for long periods. Hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are two representative examples. On the other hand, there are cases, where viral replication discontinuously occurs without clearance after primary infection. Depending on viral persistency, this discontinuous infection can be further divided into latent infection or slow infection. In the case of latent infection, viral replication occurs transiently during primary infection. Soon after, the virus stops replicating and becomes undetectable even in the circulating bloodstream, a period dubbed “viral latency.” During latency, the viral genome is maintained without being eliminated and occasionally, the virus resumes its replication by a process termed “reactivation.” Herpesvirus infection, such as HSV-1, is a representative of latent infection. The pattern of slow infection is similar to that of latent infection, but differs in that infection pathology becomes evident following long periods (ie, decades) of infection. Human immunodeficiency virus (HIV) infection is a representative of slow infection.

The Clinical Application of Ozonetherapy for  Herpetic Infections and Herpes Zoster
Herpetic infections are painful, depressing diseases and particularly those due to HSV-I and HSV-II are recurrent. They cannot be underestimated because they procure a very poor quality of life. It appears that both herpetic infections and the fearful HZ with the possible combination of PHN can be treated reasonably well with either antiviral drugs or ozonetherapy. However, for the many patients, who suffer more or less frequently of these affections, this is an unsatisfactory information because they only want to know which is the most rapid and effective treatment. It would be a great advancement if we could programme a comparative study including three arms: antivirals, ozonetherapy and both. Such a huge study involves hundreds of patients, many clinicians and great resources for various analyses and it is beyond our possibility. Only imaginative public-health leaders could undertake this endeavour but do they exist?


Meantime the solution that may yield the best and lasting result (if not the cure) can be obtained by COMBINING the orthodox antiviral agents with ozonated major plus minor autohaemotherapy and topical application of ozonated oil. Genital herpes is the infection that often causes severe psychological effects and the majority of patients feel devastated when they learn the diagnosis. This is the reason why we strongly recommend a combination therapy carried out for a prolonged period and likely to reduce recurrency and the risk of transmission.

17 Jul '18


Posted by Marin Crangaci

Pathophysiology of pain

The province of medicine is to preserve and restore health and to relieve suffering. Understanding pain is essential to both of these goals. Because pain is universally understood as a signal of disease ít is the most common symptom that brings a patient to a physician's attention. The fuction of the pain sensory system is to protect the body and maintain homeostasis. It does this by detecting, localizing, and identifying potential or actual tissue-damaging processes. Because different diseases produce characteristic patterns of tissue damage, the quality, time course, and location of a patient's pain lend important diagnostic clues. It is the physician's responsibility to provide rapid and effctive pain relief.

The pain sensory system

Pain is an unpleasant sensation localized to a part of the body. It is often described in terms of a penetrating or tissue-destructive process (e.g. stabbing, burning, twisting, tearing, squeezing) and/or of a bodily or emotional reaction (terrifyng, nauseating, sickening). Furthermore, any pain of moderate or higher intensity is accompanied by anxiety and the urge to escape or terminate the feeling. These properties illustrate the duality of pain: it is both sensation and emotion. When it is acute, pain is characteristically associated with behavioral arousal and a stress response consisting of increased blood pressure, heart rate,  pupil diameter, and plasma cortisol levels. In addition, local muscle  contraction (e.g. limb flexion, abdominal wall rigidity) is often present.

Classification of Pain

Classification of pain: Classifying pain is helpful to guide assessment and treatment. There are many ways to classify pain and classifications may overlap. The common types of pain include:

  • Nociceptive: represents the normal response to noxious insult or injury of tissues such as skin, muscles, visceral organs, joints, tendons, or bones.
    • Examples include:
      • Somatic: musculoskeletal (joint pain, myofascial pain), cutaneous; often well localized
      • Visceral: hollow organs and smooth muscle; usually referred
  • Neuropathic: pain initiated or caused by a primary lesion or disease in the somatosensory nervous system.
    • Sensory abnormalities range from deficits perceived as numbness to hypersensitivity (hyperalgesia or allodynia), and to paresthesias such as tingling.
    • Examples include, but are not limited to, diabetic neuropathy, postherpetic neuralgia, spinal cord injury pain, phantom limb (post-amputation) pain, and post-stroke central pain.
  • Inflammatory: a result of activation and sensitization of the nociceptive pain pathway by a variety of mediators released at a site of tissue inflammation.
    • The mediators that have been implicated as key players are proinflammatory cytokines such IL-1-alpha, IL-1-beta, IL-6 and TNF-alpha, chemokines, reactive oxygen species, vasoactive amines, lipids, ATP, acid, and other factors released by infiltrating leukocytes, vascular endothelial cells, or tissue resident mast cells
    • Examples include appendicitis, rheumatoid arthritis, inflammatory bowel disease, and herpes zoster.

Clinical Implications of classification: Pathological processes never occur in isolation and consequently more than one mechanism may be present and more than one type of pain may be detected in a single patient; for example, it is known that inflammatory mechanisms are involved in neuropathic pain.

  • There are well-recognized pain disorders that are not easily classifiable. Our understanding of their underlying mechanisms is still rudimentary though specific therapies for those disorders are well known; they include cancer pain, migraine and other primary headaches and wide-spread pain of thefibromyalgia type.

Pain Intensity: Can be broadly categorized as: mild, moderate and severe. It is common to use a numeric scale to rate pain intensity where 0 = no pain and 10 is the worst pain imaginable:

  • Mild: <4/10
  • Moderate: 5/10 to 6/10
  • Severe: >7/10

Time course: Pain duration

  • Acute pain: pain of less than 3 to 6 months duration
  • Chronic pain: pain lasting for more than 3-6 months, or persisting beyond the course of an acute disease, or after tissue healing is complete.
  • Acute-on-chronic pain: acute pain flare superimposed on underlying chronic pain.


In clinical practice, ozone injections have a high frequency of success in treating joint pain. Indeed, clinical reports abound of patients who were scheduled for joint replacement surgery and ended up postponing it because of complete or acceptable symptom amelioration from ozone treatment. Knee and shoulder joints appear to be the most responsive joints to treatment, while hip joints are the most challenging to treat successfully, even with the assistance of ultrasound guidance.

Dental pain also tends to respond well to treatment, whether it is post-root canal, trauma-induced, or idiopathic. I have observed trigger points and symptom-inducing scar tissue to regularly resolve more easily when ozone is added into the treatment protocol. Nasal inhalation of ozone gas that has been percolated through olive oil frequently works very well for pain from acute or chronic sinusitis (it must be noted that if ozone is inhaled without percolating it in oil, it is very irritating and damaging to the lungs30). Patients suffering from chronic infections such as Lyme or its coinfections (eg, Bartonella, Erlichia, Babesia, etc) often have faster symptom resolution when using ozone injections in painful muscles or joints. Such amelioration may be due to a combination of the anti-inflammatory effects of ozone and its antimicrobial properties.
Systemic administration of ozone, as in major autohemotherapy, can be of great benefit in chronic pain syndromes like fibromyalgia, chronic fatigue syndrome, autoimmune disorders, etc. In some cases, MAH as a standalone treatment can provide symptom relief; however, in the majority of cases, additional interventions are required. Given that the proposed mechanisms of MAH revolve around the enhancement of antioxidant status, mitochondrial function, and immunomodulation, it stands to reason that supportive dietary and lifestyle changes, supplements, and other therapies would be required to enhance its effects. Indeed, the effects of MAH rarely reach their full potential without the following: an anti-inflammatory diet, exercise to tolerance, adequate nutrient status (especially B vitamins, magnesium, mitochondrial support factors), endocrine support (thyroid, adrenals, etc), unimpeded liver function and emunctories, and support towards a healthy milieu (ie, balanced microbes, pH, autonomic function, mental/emotional state, methylation, etc). In short, systemic ozone therapy can be a powerful complement to what we already specialize in as naturopathic doctors.