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How Does Ozone Act? How and Why Can WeAvoid Ozone Toxicity? Therefore it should be clear that some of ozone dose is neutralized by the antioxidants present in plasma and only the reaction with PUFA is responsible for the biological and therapeutic effects. This should clarify why a very low ozone dose can be ineffective or equivalent to a placebo. Moreover, after ozonation of human blood, the antioxidant capacity measured in plasma decreases no more than 30% after about 5 min but returns to the normal value during t he following 15 min, thanks to the rapid r eduction of t...

This article is a third part of the series of articles with the generic "Science behind ozone therapy".  In this part we want to describe how ozone interact and change effect of ROS and its benefic effects. Ozone, the triatomic oxygen, synthesized in the stratosphere to protect us from excessive UV radiation, can be precisely produced with a medical generator but it is up to us to use it proficiently as a real drug. As ozone is one of the most potent oxidants; the third in the chemical scale, we must learn how to tame it and the scope of...

This article is a second part of the series of articles with the generic "Science behind ozone therapy".  In this part we want to  describe some of the fundamentals of ozone and its pharmacodynamics as well as the impact ozone has on the immune system. The characteristics of ozone as a potent oxidant is fundamental in its effect on physiology and the immune system. These topics are discussed in some detail as it pertains to ozone as a medical treatment using various modalities. To understand about we speak for first we need to define some terms: Pharmacodynamics: Molecular Mechanisms of...

Ozone therapy has been marred by conventional science for years due to many flawed experimental designs or small sample sizes of the population in which it intends to study. For this reason, many physicians have dismissed ozone therapy and limited funds have been delegated to furthering the knowledge of its therapeutic effects. However, there is evidence that suggests that ozone does have various therapeutic effects that range from disinfection of pathogens, anticancer properties, and treatment of back ailments. In general meaning, ozone therapy results in the short-term production of reactive oxygen species such as hydrogen peroxide, and the long-term production...