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   In 2009 a group of scientists (Hee Su Kim, Sun Up Noh, Ye Won Han, Kyoung Moon Kim, Hoon Kang, Hyung Ok Kim and Young Min Park) from Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, undertook a study in which they researched  the therapeutic effects of topical ozonated olive oil on acute cutaneous wound healing in a guinea pig model and also to elucidate its therapeutic mechanism. After creating full-thickness skin wounds on the backs of guinea pigs by using a 6 mm punch biopsy, they examined the wound healing effect of topically applied ozonated olive...

Germicidal Properties of Ozonated Oil   Ozone is a well-known allotropic form of oxygen and a very strong oxidative agent. Due to this property it is one of the strongest disinfectants. Its biocidal activity was discovered by Fox in 1873. Ozone was first used in medicine in 1894 by Labbe and Oudin for tuberculosis treatment. The 20th century brought many new applications for ozone germicidal properties. A gaseous mixture of ozone and air was used in 1915 for wound disinfection by Wolff. In 1935 it was used in dental medicine by Fisch and in surgery by Payr (Viebahn-Hansler, 2002).   Ozone...

 In previous article we started to speak about ozone mechanism of action and how we can avoid ozone toxicity. We spoke about “ozone messengers” and their pharmacodynamics.   Today we will continue with  biological effects elicited during exposure of human blood to ozone.    There is an ample literature regarding the cytotoxicity of LOPs . These compounds, when tested either in tissue culture, or examined in the context of the delicate respiratory system, are toxic even at a concentration of 1 μM. Surprisingly, submicromolar concentrations (0.01–0.5 μM) tested in several cell types can stimulate proliferation and useful biochemical activities. These findings lead to...

How Does Ozone Act? How and Why Can WeAvoid Ozone Toxicity? Therefore it should be clear that some of ozone dose is neutralized by the antioxidants present in plasma and only the reaction with PUFA is responsible for the biological and therapeutic effects. This should clarify why a very low ozone dose can be ineffective or equivalent to a placebo. Moreover, after ozonation of human blood, the antioxidant capacity measured in plasma decreases no more than 30% after about 5 min but returns to the normal value during t he following 15 min, thanks to the rapid r eduction of t...